InSiGHT houses and curates the most comprehensive database of DNA variants in the genes that contribute to gastrointestinal cancer, but a number of other institutions provide databases, each with different characteristics.

The InSiGHT databases are supported by curators, and panels of experts who review the pathogenicity assignments. Most of the databases are considered to present the most authoritative interpretation of the variants, based on defined criteria for interpretation. The data are published with the rider that they are for diagnostic use for individual families; any research use requires permission of the curator and relevant submitters.