Revised criteria for HNPCC

Amsterdam criteria I (the classical criteria):
There should be at least three relatives with histologically verified CRC; all the following criteria should be present:
1) one should be a first degree relative of the other two;
2) at least two successive generations should be affected;
3) at least one CRC should be diagnosed before age 50;
4) FAP should be excluded in the CRC case;
5) tumors should be verified by pathological examination

Amsterdam criteria II:
There should be at least three relatives with an HNPCC-associated cancer (CRC, cancer of the endometrium, small bowel, ureter or renal pelvis);
all the following criteria should be present:
1) one should be a first degree relative of the other two;
2) at least two successive generations should be affected;
3) at least one cancer should be diagnosed before age 50;
4) FAP should be excluded in the CRC case (if present)
5) tumors should be verified by pathological

Surveilalance

site	procedure	lower age limit (yrs)	interval (yrs)
colon	colonoscopy	20-25	2
endometrium (+ ovaries)	gynaecological examination transvaginal sonography CA-125	30-35	1-2
stomach	gastroscopy	30-35	1-2
urinary tract	sonography urinary analysis	30-35	1-2

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